Isabel "Izzy" Spellman, a San Francisco private eye with a checkered past, has been working for her family's firm, Spellman Investigations, since age 12. Now 28, Izzy thinks she wants out of the family business, but elects to take on a cold case while dealing with her 14-year-old sister Rae, a nightmarish Nancy Drew, and parents who have no qualms about bugging their children's bedrooms. When Rae suddenly disappears, Izzy and her family must learn some serious lessons in order to find her.