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The Gene: An Intimate History de Siddhartha…
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The Gene: An Intimate History (original: 2016; edição: 2016)

de Siddhartha Mukherjee (Autor)

MembrosResenhasPopularidadeAvaliação médiaMenções
1,692587,513 (4.18)113
The Pulitzer Prize-winning author draws on his scientific knowledge and research to describe the magisterial history of a scientific idea, the quest to decipher the master-code of instructions that makes and defines humans; that governs our form, function, and fate; and that determines the future of our children. The story of the gene begins in earnest in an obscure Augustinian abbey in Moravia in 1856 where Gregor Mendel, a monk working with pea plants, stumbles on the idea of a "unit of heredity." It intersects with Darwin's theory of evolution, and collides with the horrors of Nazi eugenics in the 1940s. The gene transforms postwar biology. It invades discourses concerning race and identity and provides startling answers to some of the most potent questions coursing through our political and cultural realms. It reorganizes our understanding of sexuality, gender identity, sexual orientation, temperament, choice, and free will, thus raising the most urgent questions affecting our personal realms. Above all, the story of the gene is driven by human ingenuity and obsessive minds--from Mendel and Darwin to Francis Crick, James Watson, and Rosalind Franklin to the thousands of scientists working today to understand the code of codes. Woven through the book is the story of Mukherjee's own family and its recurring pattern of schizophrenia, a haunting reminder that the science of genetics is not confined to the laboratory but is vitally relevant to everyday lives. The moral complexity of genetics reverberates even more urgently today as we learn to "read" and "write" the human genome--unleashing the potential to change the fates and identities of our children and our children's children.--Adapted from dust jacket.… (mais)
Membro:Robert_Musil
Título:The Gene: An Intimate History
Autores:Siddhartha Mukherjee (Autor)
Informação:Scribner (2016), Edition: 1, 608 pages
Coleções:Read, Sua biblioteca
Avaliação:*****
Etiquetas:stem, startups-tech-sv, biotech, medicine-health-care

Detalhes da Obra

The Gene: An Intimate History de Siddhartha Mukherjee (2016)

  1. 00
    p53: The Gene that Cracked the Cancer Code de Sue Armstrong (rodneyvc)
  2. 00
    A Brief History of Everyone Who Ever Lived: The Human Story Retold Through Our Genes de Adam Rutherford (jigarpatel)
    jigarpatel: Summary of how humans have evolved with evidence found in genetics; interesting follow-up to Gene: An Intimate History.
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Mostrando 1-5 de 58 (seguinte | mostrar todas)
Because I work in computational biology, focusing on related minutae all day, this hit especially home. I had learned a lot of the broad scientific strokes in school but less the other parts. I was especially interested in the Asilomar conference and Schrödinger's book which kept coming up. The ending was really thoughtful and well done, although I'll admit (as Mukherjee acknowledges), his likely future is pretty disconcerting. I do believe there will be common-place crispr-related human therapy coming soon and the germline modification will come soon after. Every one of the example usages has so many ways of going wrong in subtle but disastrous and permanent ways ( )
  Lorem | Mar 6, 2021 |
Gosh, this book just drags on and on and on. It is quite interesting but it just won't end and at leat to me whose knowledge of biology is extremely restricted (apart from some stuff on behavioral genetics I know virtually nothing of that discipline) this is a serious problem as (especially beginning with the history of genetics in the 20th century) there is just too much content and it gets impossible to decide what is actually important and what not causing me to remember some nice facts but being unable to retell the whole big picture. It's just a fractured narrative which is not presented that well and loses itself in technicalities. ( )
  aeqk | Dec 13, 2020 |
There is lots of interesting stuff in this packed book - and that ends up being its downfall. There is just so much that I often found myself skimming. The topics are far ranging and thought provoking. Unfortunately, the personal storyline is never really given any kind of conclusion, which is disappointing. But there is a wealth of information about genes and both the discovery and history of cellular blueprints as well as all the ethical considerations that have arisen as science has developed. ( )
  tjsjohanna | Oct 16, 2020 |
2016 (review can be found at the link - which is a LibraryThing page)
https://www.librarything.com/topic/226898#5718349 ( )
  dchaikin | Jun 21, 2020 |
Thanks goes to Netgalley and a wonderful author for a wonderfully told series of stories within the world of genetics.

I was worried, briefly, by the insistence of bringing Aristotle's take on the genome, or the recapitulation of many of the grandfathers of the science, such as Mendel and Darwin, but the way that these otherwise well-known personages were brought alive to the page was more of a story than a dry recounting. Even so, I wasn't prepared for what was soon to come.

I became engrossed in the history of American Eugenics, and even more so in Germany's frightful improvements, all of which painted the history of the science in quite a dark, and ignorant, light.

Fortunately for all of us, Crick, Watson, and Ferdinand come out swinging and we can see this all as a heroic step forward... even considering the fact that Ferdinand never got to see her work truly recognized.

From here on out, we've got truly wonderful tales of Beck and the birth of recombinant DNA, scientists self-policing, the rise of multinational bio-engineering firms, AIDS, gene therapies, genome mapping, and of course cloning and stem-cell blocking, and each and every one of these stories are bright and very readable.

And what's more, it's always informative and it's always interesting. It even draws us in to the author's own deep and emotional familial history and his own drive to understand.

I'll make no bones about it: I was moved.

I've read more than a handful of books on genetics in the past, and while some were quite good and some were sometimes mesmerizingly boring, I think this one has got to be the most readable, grab you on the human level, and most in depth survey of the entire field that I've ever read.

So many disparate characteristics managed to encode the proteins of the narrative, and no one could be happier than me to see such a healthy and shining phenotypical expression be borne from a popular book. It's classy and smart. Very smart. In fact, it's pretty much a must-have if you're a science-history buff bringing us up to the cutting-edge present and want a few questions for the future. :)

( )
  bradleyhorner | Jun 1, 2020 |
Mostrando 1-5 de 58 (seguinte | mostrar todas)
The story of this invention and this discovery has been told, piecemeal, in different ways, but never before with the scope and grandeur that Siddhartha Mukherjee brings to his new history, “The Gene.” ... As he did in his Pulitzer ­Prize-winning history of cancer, “The Emperor of All Maladies” (2010), Mukherjee views his subject panoptically, from a great and clarifying height, yet also intimately.
 
... By the time “The Gene” is over, Dr. Mukherjee has covered Mendel and his peas, Darwin and his finches. He’s taken us on the quest of Watson, Crick and their many unsung compatriots to determine the stuff and structure of DNA. We learn about how genes were sequenced, cloned and variously altered, and about the race to map our complete set of DNA, or genome, which turns out to contain a stunning amount of filler material with no determined function.

...Many of the same qualities that made “The Emperor of All Maladies” so pleasurable are in full bloom in “The Gene.” The book is compassionate, tautly synthesized, packed with unfamiliar details about familiar people....

... “The Gene” is more pedagogical than dramatic; as often as not, the stars of this story are molecules, not humans. Dr. Mukherjee still has a poignant personal connection to the material — mental illness has wrapped itself around his family tree like a stubborn vine, claiming two uncles and a cousin on his father’s side — but this book does not aim for the gut. It aims for the mind...
adicionado por rybie2 | editarNew York Times, Jennifer Senior (May 8, 2016)
 

» Adicionar outros autores (4 possíveis)

Nome do autorFunçãoTipo de autorObra?Status
Siddhartha Mukherjeeautor principaltodas as ediçõescalculado
Boutsikaris, DennisNarradorautor secundárioalgumas ediçõesconfirmado
Drost-Plegt, TraceyTradutorautor secundárioalgumas ediçõesconfirmado
Veen, René vanTradutorautor secundárioalgumas ediçõesconfirmado
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An exact determination of the laws of heredity will probably work more change in man's outlook on the world, and in his power over nature, than any other advance in natural knowledge that can be foreseen.
—William Bateson
Human beings are ultimately nothing but carriers—passageways—for genes.  They ride us into the ground like racehorses from generation to generation.  Genes don't think about what constitutes good or evil.  They don't care whether we are happy or unhappy.  We're just means to an end for them.  The only thing they think about is what is most efficient for them.
—Haruki Murakami, IQ84
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To Priyabala Mukherjee (1906-1985), who knew the perils;
to Carrie Buck (1906-1983), who experienced them.
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In the winter of 2012, I traveled from Delhi to Calcutta to visit my cousin Moni.
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The Pulitzer Prize-winning author draws on his scientific knowledge and research to describe the magisterial history of a scientific idea, the quest to decipher the master-code of instructions that makes and defines humans; that governs our form, function, and fate; and that determines the future of our children. The story of the gene begins in earnest in an obscure Augustinian abbey in Moravia in 1856 where Gregor Mendel, a monk working with pea plants, stumbles on the idea of a "unit of heredity." It intersects with Darwin's theory of evolution, and collides with the horrors of Nazi eugenics in the 1940s. The gene transforms postwar biology. It invades discourses concerning race and identity and provides startling answers to some of the most potent questions coursing through our political and cultural realms. It reorganizes our understanding of sexuality, gender identity, sexual orientation, temperament, choice, and free will, thus raising the most urgent questions affecting our personal realms. Above all, the story of the gene is driven by human ingenuity and obsessive minds--from Mendel and Darwin to Francis Crick, James Watson, and Rosalind Franklin to the thousands of scientists working today to understand the code of codes. Woven through the book is the story of Mukherjee's own family and its recurring pattern of schizophrenia, a haunting reminder that the science of genetics is not confined to the laboratory but is vitally relevant to everyday lives. The moral complexity of genetics reverberates even more urgently today as we learn to "read" and "write" the human genome--unleashing the potential to change the fates and identities of our children and our children's children.--Adapted from dust jacket.

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